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In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein - a 2 minute Preview of the Experimental Protocol

Dexin Sui, Mengyu Liu, Min-Hao Kuo
Michigan State University, Department of Biochemistry and Molecular Biology;

Unmodified and hyperphosphorylated tau proteins were used in two in vitro aggregation assays to reveal the hyperphosphorylation-dependent fast aggregation kinetics. These assays pave the way for future screens for compounds that can modulate the propensity of hyperphosphorylated tau to form fibrils that underlie the progression of Alzheimer’s disease.

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