Rajwanth Veluswamy, MD, Icahn School Of Medicine At Mount Sinai, New York, NY, gives an overview of the MAPK signaling pathway in cancer and the development of pan-RAF inhibitors. The MAPK pathway consists of various protein kinases and the most common mutation seen in lung cancer is the V600E mutation in BRAF. Overall, BRAF mutations can be divided into class I, II or III, where V600E mutations fall into class I mutations. Pan-RAF inhibitors do not target specific BRAF mutations and are currently under investigation in clinical trials. This interview took place at 2024 Targeted Therapies of Lung Cancer Meeting (TTLC 2024) in Santa Monica, CA.
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