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With age, insufficient tryptophan in the diet alters the gut microbiota and increases inflammation. In aged mice, eight weeks on a low-tryptophan diet results in some unhealthy changes in the trillions of bacteria that comprise the gut microbiota and higher levels of systemic inflammation, according to a new study. The research was funded by the National Institute on Aging, or NIA. The researchers fed the aged mice three different diets for eight weeks — diets that were deficient, had recommended levels and high levels of tryptophan. In the face of low tryptophan, they saw both a direct and indirect impact on the microbiota and it generally set the stage for inflammation body-wide according to the researchers. There were reduced levels of certain bacteria species, which also had been seen in patients with Crohn’s and colitis. The unhealthy changes made the researchers suspect increased release of inflammation-promoting signaling molecules called cytokines, hypothesizing that microbiota changes might induce release of cytokines body-wide. They found significant increases of IL-6, IL-17A and IL-1a and a significant decrease in IL-27, a cytokine which prevents transcription of inflammation-invoking IL-17 and helps do things like increase regulatory T cells in the gut, which suppress inflammation. Conversely, mice on a tryptophan-rich diet had higher levels of calming IL-27.
Thomas DeLauer's video about Dr. David Sinclair's research: [ Ссылка ]
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#microbiome #aging #longevity #aminoacids #molecularbiology
