Pharmacology Of Heparin (Parenteral Anticoagulant) by Dr. Shikha Parmar
Heparin is an anticoagulant that stimulates antithrombin III (ATIII) which then inhibits coagulation factors VII, IX, X, XI, XII, as well as thrombin. This leads to prevention of thrombus formation (anticoagulation)...Heparin is used for ICU anticoagulation...Adverse effects of heparin includes bleeding, Heparin-induced thrombocytopenia (HIT), and osteoporosis.
Anticoagulants, commonly known as blood thinners, are chemical substances that prevent or reduce coagulation of blood, prolonging the clotting time. Some of them occur naturally in blood-eating animals such as leeches and mosquitoes, where they help keep the bite area unclotted long enough for the animal to obtain some blood. As a class of medications, anticoagulants are used in therapy for thrombotic disorders. Oral anticoagulants (OACs) are taken by many people in pill or tablet form, and various intravenous anticoagulant dosage forms are used in hospitals. Some anticoagulants are used in medical equipment, such as sample tubes, blood transfusion bags, and dialysis equipment. They can also be used as rodenticides.
Some of the more well-known ones are heparin and fondaparinux.
(1) Apixaban (Eliquis)
(2) Dabigatran (Pradaxa)
(3) Edoxaban (Savaysa)
(4) Fondaparinux (Arixtra)
(5) Heparin (Fragmin, Innohep, and Lovenox)
(6) Rivaroxaban (Xarelto)
(7) Warfarin (Coumadin, Jantoven)
