Healthy cells regulate gene transcription as an essential checkpoint to prevent uncontrolled cellular growth that leads to disease.
Watch this video to learn more about how RNA Polymerase II and the Super Elongation protein complex (SEC) influence gene transcription and how their misregulation may lead to disease.
Researchers in Shilatifard’s laboratory are studying these mechanisms in order to understand the evolution of cancer and potentially discover targets for novel cancer therapeutics.
This video was produced by Dani Bergey from the Biomedical Visualization graduate program at the University of Illinois at Chicago.
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