Infectious disease experts Adam Lauring, MD, PhD, and Carlos del Rio, MD, join JAMA Associate Editor Preeti Malani, MD, MSJ, for a discussion of the newly emerged Omicron variant, the potential for a 2021-2022 "twindemic" with flu, and the latest COVID-19 clinical updates. Recorded December 1, 2021.

Topics discussed in this interview:
0:00 Introduction
02:17 Mutations in Omicron Variant
03:23 Could Omicron have emerged in a patient with immunosuppression
07:33 CDC steps to respond to Omicron
10:03 Next steps for laboratory testing
11:02 Travel restrictions
11:19 Accuracy of different COVID-19 tests
12:22 Challenges of genetic sequencing
16:28 Therapeutics, monoclonal antibodies, oral antivirals
21:48 Vaccine effectiveness
25:03 Vaccine hesitancy
32:09 COVID-19 and Flu "twindemic"
35:32 Cases identified in the US
36:22 Taking care of mental health for physicians
28:42 What to look forward to

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