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Vitamin B1 (Thiamin): Daily requirements, Sources, Functions, Deficiency and manifestations

Vit B1 (thiamine): one of its derivatives, thiamine pyrophosphate, is a cofactor for several dehydrogenase enzymes that work on α-ketoacids (e.g. pyruvate, α-ketoglutarate)
• Deficiency → beriberi, Wernicke-Korsakoff syndrome
• Beriberi has a dry (neuropathy) and wet (high output heart failure) component.
Wernicke-Korsakoff is a syndrome of Wernicke’s encephalopathy (triad of confusion, ophthalmoplegia, and ataxia) and Korsakoff’s psychosis (memory loss, confabulation and personality change).

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