Listen as Dr. Adrienne Randolph discusses the epidemiology, clinical characteristics, and outcomes observed in pediatric patients diagnosed with Severe Acute COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C). She shares insights into patient features that can help distinguish between these conditions, potentially facilitating the delivery of timely and effective therapies.
After this podcast, listeners will be able to:
• Contrast the key clinical characteristics of children and adolescents diagnosed with MIS-C versus severe acute COVID-19
• Describe key concerns relating to pediatric COVID-19 vaccine development and pediatric public health measures such as school reopening
Articles referenced:
• Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074-1087. doi:10.1001/jama.2021.2091 (00:47)
• Ferdinands JM, Olsho LE, Agan AA, et al. Effectiveness of influenza vaccine against life-threatening RT-PCR-confirmed influenza illness in US children, 2010-2012. J Infect Dis. 2014;210(5):674-683. doi:10.1093/infdis/jiu185 (01:42)
• Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680 (02:59)
• Truong DT, Trachtenberg FL, Pearson GD, et al. The NHLBI Study on Long-terM OUtcomes after the Multisystem Inflammatory Syndrome In Children (MUSIC): Design and Objectives. Am Heart J. 2022;243:43-53. doi:10.1016/j.ahj.2021.08.003 (11:52)
• LaRovere KL, Riggs BJ, Poussaint TY, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021;78(5):536-547. doi:10.1001/jamaneurol.2021.0504 (17:53)
Initial publication: March 23, 2021.
Speakers:
Adrienne Randolph, MD, MSc
Senior Associate in Critical Care Medicine
Department of Anesthesiology, Critical Care and Pain Medicine
Boston Children's Hospital
Professor of Anaesthesia
Harvard Medical School
Jeffrey Burns, MD, MPH
Chief and Shapiro Chair, Critical Care Medicine,
Executive Chair, International Health Services,
Director, OPENPediatrics,
Senior Associate in Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine,
Boston Children's Hospital
Professor of Anesthesia, Harvard Medical School
Citation:
Randolph A, Zackin B, Daniel D, Burns JP. Characteristics and Outcomes of Children with MIS-C Compared With Severe Acute COVID-19. 3/2021. Online Podcast. OPENPediatrics. [ Ссылка ].
Resources:
Feldstein LR, Tenforde MW, Friedman KG, et al. Characteristics and Outcomes of US Children and Adolescents With Multisystem Inflammatory Syndrome in Children (MIS-C) Compared With Severe Acute COVID-19. JAMA. 2021;325(11):1074–1087. doi:10.1001/jama.2021.2091
This recording is intended to be used as an educational resource for healthcare providers. It is in no way a substitute for the independent decision making and judgment of a qualified healthcare professional. It should not be used to make a diagnosis, or to overrule the advice of a qualified health care provider, nor should it be used to provide advice for emergency medical treatment.
Please visit: www.openpediatrics.org
OPENPediatrics™ is an interactive digital learning platform for healthcare clinicians sponsored by Boston Children's Hospital and in collaboration with the World Federation of Pediatric Intensive and Critical Care Societies. It is designed to promote the exchange of knowledge between healthcare providers around the world caring for critically ill children in all resource settings. The content includes internationally recognized experts teaching the full range of topics on the care of critically ill children. All content is peer-reviewed and open access-and thus at no expense to the user.
For further information on how to enroll, please email: openpediatrics@childrens.harvard.edu
