Tamsulosin is a selective alpha 1 A and alpha 1 D adrenoceptor antagonist, that is mainly used in the treatment of benign prostatic hyperplasia. Prostatitis. Ureteral stones. And female voiding dysfunction.
Alpha 1 A and 1 D receptors are commonly found in the prostate and sub maxillary tissue. And alpha 1 B receptors are mainly found in aorta and spleen. Blocking of alpha 1 receptors will lead to relaxation of prostatic smooth muscle cells, and reduction of obstructive symptoms associated with benign prostatic hyperplasia. Additionally, blocking of alpha 1 D receptors causes relaxation of the detrusor muscle of the bladder, and reduction of storage symptoms such as altered bladder sensation. Increased daytime frequency. Nocturia. And urinary urgency.
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