Taking immediate preventive measures to arrest any human-to-human transmission of the Wuhan coronavirus in Singapore is more important than waiting for a potential vaccine that could take years to launch, says Yee Sin Leo from the National Centre for Infectious Diseases in Singapore.

Chinese health authorities said Tuesday that the coronavirus outbreak has killed 106 people and infected 4,515.

The officials also said 60 people had been discharged.

The majority of the reported cases are in mainland China, where local authorities have quarantined several major cities and canceled Lunar New Year’s events in Beijing and elsewhere.

The Centers for Disease Control and Prevention on Tuesday expanded its Level 3 travel advisory for China, asking Americans to “avoid all nonessential travel to China.” The advisory was previously just for Wuhan, China, the epicenter of the disease’s outbreak and where the majority of cases have been reported.

The U.S. Department of State on Monday raised its travel advisory for China from Level 2 to Level 3 asking Americans to “reconsider travel to China due to the novel coronavirus.” They added that some areas have “added risk.”

President Donald Trump addressed the matter in a tweet Monday, saying the U.S. is “in very close communication with China concerning the virus.”

Multiple cases of the virus have been confirmed in Hong Kong, Macao, Taipei, Thailand, Vietnam, South Korea, Singapore, Malaysia, Japan, Australia, France and the United States.

On Monday, local authorities in Germany confirmed the country’s first case. Nepal has confirmed one case. Cambodia confirmed its first case on Monday, according to Reuters, citing Health Minister Mam Bunheng. Sri Lanka also confirmed its first case on Monday, Reuters reports.

Several companies, including Walt Disney with its Shanghai Disney, are suspending operations until further notice during the normally festive weeklong Lunar New Year holiday to prevent the outbreak from spreading. Starbucks and McDonald’s also closed stores in Hubei province.

The Centers for Disease Control and Prevention confirmed Sunday a fifth U.S. case of the coronavirus — a patient in Maricopa County, Arizona, who recently traveled to Wuhan, China.

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