1. Load up the final story mission "Extraction" (via the main menu Advanced options) on Story Mode difficulty.
2. Get to the point early in the mission where you drop down to the sewers (after being chased by tons of Volatiles).
3. As seen in the video, there will be a Screamer immediately in front of you. Kill it and then kill yourself or let the Volatiles that spawn kill you.
4. Press Space/A/X to continue. With each reload after you die, begin tossing your grenade/explosive trap/etc toward the Screamer immediately.
5. Very quickly shoot the Screamer with any gun, crossbow, or bow before it begins to scream. As always, crossbows and bows are best because you can craft your own ammo, but since this is very early in the mission you'd be fine to start over and go buy ammo.
6. Run to where your grenade landed and die in the explosion. You should have enough time to reload your gun during this short wait if necessary.
7. Rinse and repeat. Beginning to throw your grenade before the screen has even fully loaded helps a great deal.
8. Do this for the first (Kill 50), second (Kill 100), and third (Kill 200) "Lullaby" quests.

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