This Resident Evil 3 Remake game guide video shows how to defeat Nemesis Stage 2 in the Clock Tower Plaza. The boss is now a four legged creature and Nemesis focuses on inflicting damage in melee combat. This means you should fight while maintaining a safe distance and relying on dodge mechanic. Use grenade launcher and the shotgun to weaken Nemesis - more ammo and medicine can be found nearby. Be careful when the boss starts his rooftops run - he'll perform a big jump once that's over and you can't be close to where Nemesis plans to land if you don't want to receive huge damage. Keep fighting until a cut-scene starts showing Nemesis's defeat.
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