Antileprotic drugs
Leprosy is a chronic contagious skin disease causing serious and permanent damage of the body including loss of fingers,nose,etc
First line drugs-rifampicin,dapsone,clofazimine,ethionamide and protionamide
Second line drugs-quinolones,minocycline,clarithromycin
Dapsone-inhibition of PABA incorporation into folic acid
Rifampicin-Rapidly bactericidal,binds to DNA dependent RNA polymerase and inhibits RNA synthesis in bacteria
Clofazimine-Riminophenazine dye,leprostatic and anti-inflammatory
Ethionamide-Used in MDR patients who cannot tolerate clofazimine
Minocycline-high lipophilicity tetracycline,penetrates into M,leprae
Clarithromycin-macrolide antibiotic
Fluoroquinolones-ofloxacin-lepricidal-MDR
Lepra reactions-Immunologically mediated reactions that occur during the course of disease.
Precipitated by acute infections,stress,anxiety and treatment with dapsone
