The Cardinals came out and made a statement over Austin Peay in their opener, 62-0. UL quarterback Tyler Shough passed for 232 yards and four touchdowns. Running back Isaac Brown rushed for 123 yards on 5 carries, 77 of those yards came on a fantastic TD rush. Ja'Corey Brooks hauled in 7 receptions for 83 yards and a score in his debut for Louisville. The defense for UL scored their first TD of the season on a Ramon Puryer scoop and score, and they also blocked a punt.

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