Dr. Ladan Zand explains challenges in the diagnosis, classification and treatment of Focal segmental glomerulosclerosis (FSGS).
Dr. Zand is general nephrologist and Associate Professor of Medicine at the Division of Nephrology and Hypertension of Mayo Clinic in Rochester, Minnesota. Dr. Zand researches on novel therapeutic approaches in management of patients with glomerulonephritis including FSGS, IgA nephropathy, ANCA associated vasculitis, lupus nephritis, and PGNMID.


The interview was recorded on July 27th, 2023.

Moderators: Prof. Dr. Dominique Guerrot (Rouen, France), Ass.-Prof. Dr. Andreas Kronbichler (Innsbruck, Austria), Prof. Dr. Carsten Bergmann (Mainz / Freiburg, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany).

Articles discussed:

Discovery of Autoantibodies Targeting Nephrin in Minimal Change Disease Supports a Novel Autoimmune Etiology.
Watts AJB, Keller KH, Lerner G, Rosales I, Collins AB, Sekulic M, Waikar SS, Chandraker A, Riella LV, Alexander MP, Troost JP, Chen J, Fermin D, Yee JL, Sampson MG, Beck LH Jr, Henderson JM, Greka A, Rennke HG, Weins A.
J Am Soc Nephrol. 2022 doi: 10.1681/ASN.2021060794

Precision nephrology identified tumor necrosis factor activation variability in minimal change disease and focal segmental glomerulosclerosis.
Mariani LH, Eddy S, AlAkwaa FM, McCown PJ, Harder JL, Nair V, Eichinger F, Martini S, Ademola AD, Boima V, Reich HN, El Saghir J, Godfrey B, Ju W, Tanner EC, Vega-Warner V, Wys NL, Adler SG, Appel GB, Athavale A, Atkinson MA, Bagnasco SM, Barisoni L, Brown E, Cattran DC, Coppock GM, Dell KM, Derebail VK, Fervenza FC, Fornoni A, Gadegbeku CA, Gibson KL, Greenbaum LA, Hingorani SR, Hladunewich MA, Hodgin JB, Hogan MC, Holzman LB, Jefferson JA, Kaskel FJ, Kopp JB, Lafayette RA, Lemley KV, Lieske JC, Lin JJ, Menon R, Meyers KE, Nachman PH, Nast CC, O'Shaughnessy MM, Otto EA, Reidy KJ, Sambandam KK, Sedor JR, Sethna CB, Singer P, Srivastava T, Tran CL, Tuttle KR, Vento SM, Wang CS, Ojo AO, Adu D, Gipson DS, Trachtman H, Kretzler M.
Kidney Int. 2023 doi: 10.1016/j.kint.2022.10.023.

Study Design of the Phase 3 Sparsentan Versus Irbesartan (DUPLEX) Study in Patients With Focal Segmental Glomerulosclerosis.
Komers R, Diva U, Inrig JK, Loewen A, Trachtman H, Rote WE.
Kidney Int Rep. 2020 doi: 10.1016/j.ekir.2019.12.017

The Incidence of Primary vs Secondary Focal Segmental Glomerulosclerosis: A Clinicopathologic Study.
Hommos MS, De Vriese AS, Alexander MP, Sethi S, Vaughan L, Zand L, Bharucha K, Lepori N, Rule AD, Fervenza FC.
Mayo Clin Proc. 2017 doi: 10.1016/j.mayocp.2017.09.011.

The evolving story of apolipoprotein L1 nephropathy: the end of the beginning.
Daneshpajouhnejad P, Kopp JB, Winkler CA, Rosenberg AZ.
Nat Rev Nephrol. 2022 doi: 10.1038/s41581-022-00538-3.

APOL1 Nephropathy: From Genetics to Clinical Applications.
Friedman DJ, Pollak MR.
Clin J Am Soc Nephrol. 2021 doi: 10.2215/CJN.15161219.

Focal segmental glomerulosclerosis.
D'Agati VD, Kaskel FJ, Falk RJ.
N Engl J Med. 2011 doi: 10.1056/NEJMra1106556

KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group.
Kidney Int. 2021 doi: 10.1016/j.kint.2021.05.021.

Inaxaplin for Proteinuric Kidney Disease in Persons with Two APOL1 Variants.
Egbuna O, Zimmerman B, Manos G, Fortier A, Chirieac MC, Dakin LA, Friedman DJ, Bramham K, Campbell K, Knebelmann B, Barisoni L, Falk RJ, Gipson DS, Lipkowitz MS, Ojo A, Bunnage ME, Pollak MR, Altshuler D, Chertow GM; VX19-147-101 Study Group.
N Engl J Med. 2023 doi: 10.1056/NEJMoa2202396.

Clinical Features and Histology of Apolipoprotein L1-Associated Nephropathy in the FSGS Clinical Trial.
Kopp JB, Winkler CA, Zhao X, Radeva MK, Gassman JJ, D'Agati VD, Nast CC, Wei C, Reiser J, Guay-Woodford LM, Pollak MR, Hildebrandt F, Moxey-Mims M, Gipson DS, Trachtman H, Friedman AL, Kaskel FJ; FSGS-CT Study Consortium.
J Am Soc Nephrol. 2015 doi: 10.1681/ASN.2013111242

Music in the Credits:

Klaviersonate Nr. 26 Les Adieux in es-dur, op. 81a - III.Vivacissamente
Klaviersonate Nr. 32 in c-moll, op. 111 - II. Arietta Adagio molto, semplice e cantabile
Ludwig van Beethoven / Artur Schnabel
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