clinical pharmacology of antibiotics, tetracycline antibiotics pharmacology, protein synthesis inhibitors pharmacology, tetracycline pharmacology mechanism, protein synthesis inhibitors antibiotics,
▪ Tetracyclines are antimicrobial antibiotics that inhibit bacterial ribosomes which are the organelles that make proteins. Tetracyclines bind to the A-site on the 30s subunit of the bacterial ribosome which inhibits the binding of tRNAs to the mRNA-ribosome complex, and shuts down protein synthesis before it even begins.
▪ Tetracyclines are divided according to their duration of action: Short acting tetracyclines, like tetracycline itself, have a half life of around 8 hours, and long acting tetracyclines ones like doxycycline and minocycline last for 16 hours or more. Administration of tetracyclines is usually topical, or per-oral, but tigecycline is used IV only.
▪ Tetracyclines are broad spectrum, meaning they can target a wide variety of Gram positive and negative bacteria. They are often used to treat severe acne or community acquired pneumonia. It can also be given to prevent malaria, which is a parasitic protozoa that infect blood cells and hepatocytes. Both doxycycline and tigecycline are also effective against MRSA, a notoriously tough bug that resists many common antibiotics.
▪ Counselling points about tetracycline antibiotics;
- This medication can make your skin more sensitive to the sun, and you can burn more easily. Use sunscreen, wear protective clothing and avoid the sun.
- Take with a full glass of water and stay upright for 30 minutes to avoid Gl irritation.
- This medication should be taken twice daily, 1-2 hours before, or 4 - 6 hours after antacids, vitamins, magnesium, calcium, iron, zinc, dairy products.
- Do not use this medication if you are pregnant, if you could become pregnant, or if you are breastfeeding.
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Chapters:
0:00 - Tetracycline Antibiotics Pharmacology
0:40 - Tetracycline Mechanism of Action
1:10 - Classification of Tetracycline Antibiotics
2:02 - Pharmacokinetics of Tetracycline Antibiotics
2:42 - Clinical indications (uses) of Tetracycline Antibiotics
3:42 - Side Effects of Tetracycline Antibiotics
4:40 - Counselling points for Tetracycline Antibiotics
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"Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. The Video Content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition."
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