Bio Hacking Newsletter: [ Ссылка ] | Lion's Mane:: Fertilizer for Neurons [ Ссылка ] :: How it Benefits Diabetes [ Ссылка ] :: Its effect on Brain Function [ Ссылка ]
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In this video, I will be covering the medicinal properties of a Mushroom called Lion’s Mane. Lion´s mane, also known as Hericium erinaceus, is a wellknown
edible and medicinal mushroom found throughout eastern Asia. Its fruiting bodies, meaning the mushroom heads, and fungal mycelia, meaning the root-like structures, exhibit various pharmacological activities, including the enhancement of the immune system as well as anti-tumor, hypoglycemic, and anti-aging properties.
Scientific analysis has shown that the aromatic compounds hericenones C–H and erinacines A–I isolated from the fruiting body and mycelium promote nerve growth factor (NGF) synthesis in cultured astrocytes. These results highlight the usefulness of H.
erinaceus for the treatment and prevention of dementia.
However, the biochemical mechanism responsible for this action is not yet totally understood. In Japan, the fungus is known colloquially as yamabushitake, while
it is called the monkey’s head mushroom in China and the lion’s mane mushroom in the US. Hericium erinaceus colonizes both living and dead broadleaf trees and is distributed around the world.
This video will briefly explore some of the medically useful properties of Lion’s Mane, including its effects on nerve growth factor and cognitive function. Also I will be discussing the anti-cancer, immune-enhancing, and hypoglycemic effects of the mushroom. Finally, the effects of Lion’s Mane mushroom on platelet aggregation and its function as an antioxidant will be illuminated.
Lion’s Mane
Improvement of cognition
To test the effects of orally administered Lion’s Mane on cognitive function, a double-blind, parallel-group, placebo-controlled trial was performed on mildly cognitively impaired 50-80 year-old Japanese men and women. A cognitive function scale based on the Revised Hasegawa Dementia Scale (HDS-R) was used.
So in this study, 14 individuals received Lion’s Mane while the remaining 15 individuals received placebo (5). The researchers observed that the Lion’s Mane group increased their HDS-R score relative to controls depending on the time period when Lion’s Mane was consumed. Specifically, significant differences in cognitive function appeared at weeks 8, 12, and 16 of the trial. During the 4 week follow-up period, however, the score of the Lion’s Mane group dropped back down compared with the week
16 score (figure 1). Thus, Lion’s Mane is effective at reducing mild cognitive impairment but continuous intake may be necessary to maintain the beneficial effects of the fungus (5).
Anti-cancer effect
It has been demonstrated that Lion’s Mane, which primarily consists of polysaccharides, has tumor-fighting properties. However, the mechanisms by which Lion’s Mane inhibits growth of human hepatocellular carcinoma (HCC) is largely unknown. However, two studies performed by Lee et al. (8, 9) demonstrate that Lion’s Mane acts as an enhancer to sensitize apoptotic signaling mediated by doxorubicin (Dox).
These findings suggest that Lion’s Mane in combination with Dox serves as an effective tool for treating drug-resistant human hepatocellular carcinoma.
Immune-enhancing properties
Polysaccharides are the best known and most potent mushroom-derived substances that display immuno-pharmacological properties. In a trial done by Lee et al. (9), the water soluble crude polysaccharide of lion’s mane was found to upregulate or increase macrophage (ie. White blood cell) activities, like the production of nitric oxide (NO) and the expression of cytokines.
Conclusions
Hericium erinaceus is a well-known edible and medicinal mushroom. Its fruiting
bodies and the fungal mycelia exhibit various pharmacological properties, including
factors that enhance the immune system, fight cancer, lower blood glucose, and
promote nerve growth. This video reviewed evidence showing that Lion’s Mane
reduces mild cognitive impairment, although continuous intake of the fungus
may be necessary to maintain the beneficial effects. It has also been discovered that
some hericenone compounds improve NGF. A study by Mori et al. (6) reports that
Lion’s Mane contains active compounds that are not hericenones but nevertheless
stimulate NGF synthesis. Even growth of adrenal nerve cells and extension of neurites
were shown to be enhanced by fungus exo-biopolymers.
