Video 19: The Future of the Alzheimer’s Disease
In collaboration with BrainMind, Dr. Isaacson discusses the future of the Alzheimer’s Disease.

About Dr. Richard Isaacson:
Dr. Richard Isaacson is the founder and former Director of the Alzheimer’s Prevention Clinic at the Weill Cornell Memory Disorders Program. He is currently the director of Brain Health at the Atria Institute. A leading expert on Alzheimer’s Disease (AD), Dr. Isaacson is passionate about providing the latest evidence-based options for treatment and risk reduction. His research focuses on individualized clinical management of AD using emerging principles of precision medicine. He also oversees a robust AD therapeutics and education research program.

Current vs. Future
1. Currently, to detect Alzheimer’s:
● Time intensive blood test
● Biomarker Tests:
○ PET scan of the brain to find amyloid
○ Spinal tap or lumbar puncture to sample fluids around the brain

Possible Future: simple blood test might be sufficient
2. Currently, to understand the person’s risk to Alzheimer’s:
● CAT, MRI, or PET scans
○ Requires radiation
○ Time-intensive: i.e. traveling to a clinic, waiting time
Possible Future: Amyloid levels in the eyes may predict a person’s chance to develop
Alzheimer’s or show if they already have it.

Future of Alzheimer’s
● Metabolomics: looking at fluids around the body, not blood, to understand a person’s
metabolism.
● Understanding Microbiome: different types of microbial contributions to understand
which bacteria is optimal for brain health.
○ Future: Instead of blood tests or brain scans, might use the microbiome test
● Sex Differences:
○ Understanding perimenopause transition in women
■ Intervene with drug, dietary changes, or hormone replacement therapy
● Digital Therapeutics:
○ Digitally assess, capture data, and understand a person’s strength and weaknesses
○ Using AI to give personal plans
● Personalized Drug Therapies:
○ Different phenotypes require different therapeutics

Takeaways:
● The future of Alzheimer’s disease lies in both genetic advances as well as
understandings of lifestyles and environmental risks.
● There should be precision and specific nutritional plans for every individual in order to
reduce their risk of Alzheimer's.

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