Granular casts are casts that contain either proteins, tubular cells or leukocytes that have broken down. The presence of granular casts in the urine does not indicate the type of kidney disease present.
Casts in urine from normal individuals are few or none (and are usually hyaline or granular in nature). An absence of casts does not rule out renal disease. Casts may be absent or very few in cases of chronic, progressive, generalized nephritis.
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