How proteins C and S inhibit clotting factors 5 and 8 (FV and FVIII) to stop blood coagulation...Bleeding disorders.
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Protein C and protein S are vitamin K-dependent factors that inhibit blood coagulation (2ry hemostasis) by inhibiting the active factors 5 and 8 (Va and VIIIa).
They are produced in the liver via gamma carboxylation (vitamin K dependent).
We have discussed thrombomodulin in a previous video in this playlist, titled "bleeding and coagulation".
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Factor V Leiden is a genetic disorder where the factor V is mutant and therefore resistant to inactivation by the activated protein C (APC) leading to excessive thromboses (i.e. hypercoagulability). If you like my videos, please consider leaving a tip at [ Ссылка ]
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