This Specialty Testing webinar will discuss the collaborative effort that led to the discovery of Kelch-like protein 11 (KLHL11) IgG as a specific biomarker of neurological autoimmunity-associated testicular germ cell tumors. Recognizing these clinical and radiological features of KLHL11 autoimmunity can avoid delays in diagnosis. Insights into the etiopathogenic mechanism of this cytotoxic-T cell-mediated syndrome may help with formulation of therapeutic strategies. Furthermore, understanding the diagnostic potential and limitations of KLHL11 IgG detection assays may aid the managing clinicians in optimal test interpretation.
