Tycel Phillips, MD, City of Hope, Duarte, CA, gives an update on a Phase I/II study that evaluated glofitamab monotherapy with step-up dosing and obinutuzumab pretreatment in patients with relapsed/refractory (R/R) mantle cell lymphoma (MCL; NCT03075696). As Dr Phillips explains, this study suggests that fixed-duration glofitamab induces durable complete remission (CR) rates, and was associated with mostly low-grade and manageable cytokine release syndrome (CRS). This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.
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