A basic algorithmic approach to the microscopic diagnoses of inflammatory skin disease aimed at medical students, residents, general surgical pathologists, and other non-dermatopathologists. Presented virtually as the 2021 Bouldin Lectureship Grand Rounds lecture at the University of North Carolina Department of Pathology & Laboratory Medicine, April 8, 2021. All images in the video are from my Survival Guide to Dermatopathology textbook (available here: [ Ссылка ]). ‬

A complete organized library of all my videos, digital slides, pics, & sample pathology reports is available here: [ Ссылка ] (dermpath) & [ Ссылка ] (bone/soft tissue sarcoma pathology).

Topics discussed and timestamps:
***HUGE thanks to viewer Tonia Syrnioti for typing these up for me! Thank you!!!***

Intro 0:00
How to approach an inflammatory skin biopsy 5:56
Spongiotic pattern 9:16
List of diseases 11:04
Presence of eosinophils 11:46
Langerhans microabscesses 12:46
Subcorneal pustule 13:58 (spongiosis + eosinophils + subcorneal pustule: AGEP)
Do a PAS stain - think of dermatophyte infection
Scale (parakeratosis) crust (pink serum) 16:10
Psoriasiform pattern 16:58
List of diseases 19:20
Munro's microabscess 19:58
Guttate psoriasis 20:08
Psoriasiform + lichenoid + plasma cells - Do spirochete stain for secondary syphilis!
Vacuolar & Lichenoid interface pattern 20:40
Vacuolar interface pattern 20:48
List of diseases 22:38
Lichenoid interface pattern 23:38
List of diseases 23:52
Lichen planus 24:48
Hypertrophic lichen planus 26:50
Lichen sclerosus et atrophicus 28:25
Lichen simplex chronicus 32:46
Prurigo nodularis 34:36
Stevens- Johnson's syndrome/TEN 36:08 (can look identical to Erythema multiforme)
Lupus erythematosus 37:26
Discoid lupus erythematosus 38:06 (can look like AK/SCC)
Superficial perivascular pattern 38:49
List of diseases 38:58
Urticaria 39:08
Superficial & deep perivascular pattern 39:21
List of diseases 39:39
Arthropod bite reaction 40:01 (can look like bullous pemphigoid)
Wells syndrome 40:29
Perniosis (chilblains) 41:02
Granulomatous pattern 41:19
List of diseases 41:45
Remember to look for fungi & foreign material
Sarcoidosis - diagnosis of exclusion
Palisading necrobiotic granulomatous pattern 42:15
List of diseases 42:49
Granuloma annulare 43:25
Elastophagocytosis 43:35
Rheumatoid nodule 43:55
Mimic: epithelioid sarcoma 44:45
Necrobiosis lipoidica 45:38
Necrobiotic xanthogranuloma 46:00
Leukocytoclastic vasculitis pattern 46:22
List of diseases 47:58
Polyarteritis nodosa 48:05
Thrombotic vasculopathy pattern 48:34
List of diseases (often medical emergencies!!) 49:20


This video is geared towards medical students, pathology or dermatology residents, or practicing pathologists or dermatologists. Of course, this video is for educational purposes only and is not formal medical advice or consultation.

Presented by Jerad M. Gardner, MD. Please subscribe to my channel to be notified of new pathology teaching videos.

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