EnginZyme has developed an enzyme immobilization technology, EziG, which is usable for all enzyme types. Any His-tagged enzyme can be bound to the EziG carrier in a non-destructive, fast and selective way. Hereby, a pure immobilized preparation can be achieved in one step directly from cell lysate. The carrier has a core consisting of controlled pore glass where the surface is tailored by polymer coatings.

The properties of the material results in high binding capacity while the tailored surface stabilizes the enzyme catalyst. In total, this gives a non-swelling and robust porous support material suited for both aqueous and organic media. Due to the interconnecting pore structure and incompressible dense nature of glass, EziG is ideal for flow chemistry in column reactors. The immobilization procedure is simple and can be performed in the reactor itself.

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