March hemoglobinuria is a rare condition characterized by hemoglobinuria (hemoglobin in the urine) and hemolytic anemia (red blood cell destruction) induced by strenuous physical activity, typically marching or running. Laboratory findings may include:
1. Urinalysis:
- Hemoglobinuria (positive dipstick test)
- Proteinuria (excess protein in urine)
- Hematuria (red blood cells in urine)
2. Complete Blood Count (CBC):
- Anemia (low hemoglobin and hematocrit)
- Reticulocytosis (elevated reticulocyte count)
- Thrombocytopenia (low platelet count)
3. Blood Chemistry:
- Elevated bilirubin levels (total and indirect)
- Elevated lactate dehydrogenase (LDH) levels
- Low haptoglobin levels
4. Coagulation Studies:
- Prolonged prothrombin time (PT) and partial thromboplastin time (PTT)
5. Special Tests:
- Schistocyte evaluation (fragmented red blood cells)
- Heinz body preparation (denatured hemoglobin inclusions)
6. Blood Film:
- Microspherocytosis (small, spherical red blood cells)
- Schistocytes (fragmented red blood cells)
These laboratory findings indicate hemolytic anemia, red blood cell destruction, and kidney damage. It's essential to consult a healthcare professional for proper evaluation and management of March hemoglobinuria.
#marchhemoglobinuria
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