The 2022 Nobel Prize in Chemistry was awarded to Carolyn Bertozzi, Morten Meldal, and Barry Sharpless for the development of click chemistry and bioorthogonal chemistry. Each laureate played a crucial role in the click chemistry field, with Bertozzi advancing this approach into living systems by developing bioorthogonal reactions such as Staudinger ligations, which are click reactions that takes place without disrupting the cell.
Scientists leverage click chemistry in precision medicine to connect therapeutic agents with targeting molecules. In an interview with The Scientist, Bertozzi discussed how targeted degradation is a common thread that connects current bioorthogonal chemistry approaches to up-and-coming drug delivery strategies, such as proteolysis-targeting chimeras (PROTACs), lysosome-targeting chimeras (LYTACs), and the sialidases and mucinases recently created by Bertozzi’s research team for anticancer applications.
Follow The Scientist!
[ Ссылка ]
Facebook: [ Ссылка ]
Twitter: [ Ссылка ]
LinkedIn: [ Ссылка ]
Instagram: [ Ссылка ]
