The parietal cells make and release a substance known as intrinsic factor to absorb vitamin B12

Now, vitamin B12 is Very important in the production of RBCs

Without sufficient intrinsic factor, vitamin B12 goes largely unabsorbed and the body cannot produce enough normal red blood cells, leading to anemia.

Why the test is ordered

The Intrinsic blood test can help your doctor diagnose pernicious anemia if you have it.

Now, Anemia that is due to damaged parietal cells or lack of intrinsic factor is called pernicious anemia.

This is primarily an autoimmune condition that occurs when the immune system develops antibodies against parietal cells or IF

Normal Results
A normal result is called a negative result.

What Abnormal Results Mean
An abnormal result is called a positive result.

This may be due to:

Atrophic gastritis
Diabetes
Gastric ulcer
Pernicious anemia
Thyroid disease

свернуть