The work was presented at IEEE International Ultrasonics Symposium 2020.

The work was done by Yixuan Wu, Jeeun Kang, Wojciech G. Lesniak, Srikanth Boinapally, Sangeeta Ray Banerjee, Ala Lisok, Anna Jablonska, Martin G. Pomper, and Emad M. Boctor.

Prostate cancer is the second leading malignancy in male worldwide, with over a million new incidences diagnosed annually. To increase the chance of cure, early detection of aggressive prostate cancer is crucial. However, current techniques relying on prostate-specific antigen (PSA) test is limited in sensitivity and specificity with up to 75% false positive rate. To tackle the challenge, we pioneer in detecting prostate-specific membrane antigen (PSMA), which expression has been proven to correlate with the aggressiveness of prostate cancer. In this work, we collaborated with Dr. Lesniak and Dr. Pomper to develop a dual imaging agent for both fluorescence imaging and photoacoustic imaging, and validated in vivo.

Two related papers are currently under review. Will update as soon as they are publicated.

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