are you having ongoing inflammation in your hands and your feet maybe it's in a specific joint maybe it's all over in your body. In this video we're going to go a little bit deeper on this topic of inflammation look at the question how does inflammation leave the body we're going to look a little bit more at some of the triggers in the overall cascade of inflammatory events that are going to help us understand how inflammation leaves the body.
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In this video we're going to talk about how does inflammation leave the body we're going to first look at the inflammatory process how that's triggered and then we'll transition into looking at the resolution of the head formation so acute inflammation or the initiation of inflammation is usually triggered by some kind of infection and that triggering process usually happens via an interaction between pattern recognition receptors expressed on innate immune cells so immune cells that are basically sitting in your tissues kind of waiting to see what's going to happen and an evolutionary concern structure on pathogens known as pathogen-associated molecular patterns so when those pathogen-associated molecular patterns bind to the receptor on the innate immune cell that starts the cascade of inflammation in certain cytokines chemical messengers are going to be initiated inflammation can also be initiated by damage-associated molecular patterns and those are released in response to tissue damage that could be from physical tissue damage like a cut or a chemical or burn all these things are going to damage those tissues and those damage associated molecular patterns are going to bind to the innate immune cell and the cascade of events is going to follow now those will be two separate kind of events that transpire as a result of those molecules binding to the native immune cells but both are going to trigger some kind of inflammatory process so you have all those signals going on in the body in the tissues locally or sometimes systemically depending on how bad it is following that infection or damage there's some cascade of immune mediated events that follow and they follow in this sequential pattern the initial part is the acute part that we talked about in the purpose is to sort of wall off and isolate that particular problem if it's a pathogen so it doesn't spread and also to start to repair any damaged tissue that's there and of course if it is a pathogen to remove that pathogen during that phase sometimes tissues can actually get damaged by the immune cells that are there to fight the pathogen or actually repair the tissue running tissues can also sometimes get damaged that process of repair slash damage is typically kept in check by other molecules that are being produced as the cascade of events sort of progress that process of keeping the damage in check is known as the resolution part of the inflammatory cascade in this latter phase of the inflammatory process there's increased production of molecules known as lypoxins resolvins protectants and there are several others and these all contribute to the resolution of the inflammatory process now sometimes these molecules are not produced and enough abundance needed to actually resolve that damage this is thought to be behind chronic inflammatory processes or decrease healing or slow recovery from surgeries or injuries or even infections another principle likely at play here is the overall volume of inflammatory molecules relative to the resolution molecules so when immune cells are activated by the pams and dams they produce these chemical messages that will refer to as cytokines chemokines but as we age the amount of the cytokines and chemokines that are being produced actually goes up this is thought to be from more cells in general producing inflammatory signals in a process known as senescence which is common to see with aging you have more cells in this senescent phase they're sort of sending off signals that they're not healthy which recruits more immune cells to the area the problem with these cells is they're supposed to basically self-destruct but they don't so they're basically sending out these signals of increased inflammation and this may be part of what's kind of drowning out some of the signal for the resolution part of tissue injury so when there's ongoing inflammation in the body specific injury or an infection it may be that the body isn't able to produce enough of these resolving type molecules to overcome the inflammatory signal now we don't know for sure but that's certainly one of the leading theories having enough of these resolving type molecules is what allows the inflammation to actually shut off and or leave the body one key to supporting the resolution phase of the inflammatory process is having the right cell membrane configuration or cell membrane structure cell membranes are made out of.
How Does Inflammation Leave The Body?
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