Buerger's Disease, also known as Thromboangiitis Obliterans, is a medium-vessel vasculitis that is strongly associated with smoking; it is commonly seen in males younger than 40-years-old. Clinically, Buerger's disease presents with intermittent claudication, which refers to pain caused by lack of blood flow (especially during exercise). When this affects the fingers, patients can develop Raynaud phenomenon, which refers to the fingers' change in color from white to blue to red when placed under cold water. When the finger ischemia is even more severe, gangrene and autoamputation of the digits can occur (hence why "obliterans" is in the name). Buerger's disease patient may also develop superficial nodular phlebitis, which refers to pain and inflammation along veins. pathology reveals a segmental, thrombosing vasculitis with vein and nerve involvement. Smoking cessation is not curative, but it has been shown to slow progression and severity of Buerger's disease.
Learn about Buerger disease and other #medicalschool topics with Pixorize's #USMLE Step 1 mnemonics. Part of our Metabolic Disorders playlist for the USMLE Step 1 exam.
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