The nondepolarizing neuromuscular junction blockers like atracurium and rocuronium are curare-derivatives used in anesthesia for paralysis during surgery. These agents act by competitively blocking nicotinic receptors, postsynaptically at the neuromuscular junction. This prevents depolarization and inhibits muscle contraction. Train of Four stimulation will show
progressive reduction of muscle response. Neostigmine is the drug of choice to reverse these agents, and don’t forget the hypotension and respiratory depression are seen as possible side effects.
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