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Video Summary:
It's recommended that you watch the first video on oxygen hemoglobin dissociation curve before starting this video. All the basic are covered in that video. In this video we are focusing on the shift in oxygen hemoglobin dissociation curve. This video is in two parts. First I have mentioned how the binding of oxygen with hemoglobin is affected with shift in the curve. Here I have avoided siting any examples. Then in second part, we will see factors that shift the curve. Here we have increased temperature, carbon dioxide, hydrogen ion and 2,3 DPG which shift the curve to left. Shift in curve to right by increased carbon dioxide and hydrogen is also called Bohr's effect. It helps deliver more oxygen to tissues. 2,3 DPG level is increased in hypoxia and it helps in adaptation to it. Carbon monoxide shifts the curve to left. It increases affinity of hemoglobin so much that hemoglobin don't release oxygen at peripheral sites, depriving the tissue of oxygen.

🎞More videos on Respiratory Physiology:
● Transport of Gases
- Oxygen Hemoglobin Dissociation Curve: [ Ссылка ]
- Factors Shifting Oxygen Hemoglobin Dissociation Curve: [ Ссылка ]
- Oxygen Hemoglobin Dissociation Curve during Exercise: [ Ссылка ]
- Transport Of Carbon Dioxide: [ Ссылка ]
- Carbon Dioxide Dissociation Curve: [ Ссылка ]
- Haldane Effect: [ Ссылка ]
● Lung Mechanics
- Alveolar Pressure and Pleural Pressure: [ Ссылка ]
- Surface Tension in Lung Alveoli: [ Ссылка ]
- Surfactants Mechanism of Action: [ Ссылка ]
- Functions of Surfactants: [ Ссылка ]
- Compliance of Lungs: [ Ссылка ]
- Diseases Affecting Lung Compliance: [ Ссылка ]
• Ventilation & Dead Spaces in Respiratory Tract: [ Ссылка ]
• Lung Volumes and Capacities: [ Ссылка ]
• What Determines Lung Volume?: [ Ссылка ]

00:00 Introduction
00:21 What a shift means
02:38 Factors shifting the curve

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

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