Welcome to Science With Tal!

In this video, we will go over the mechanisms that underlie plasticity in the hippocampus. The hippocampus is a very important region that mediates diverse aspects of memory and many more. The mechanisms that we will cover include long-term potentiation (LTP), long-term depression (LTD) and spike-timing-dependent plasticity (STDP). We will see how these mechanisms behave both on the electrophysiological and molecular level.

This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:

1- To watch the first part (Signal propagation in the Neuron), make sure to go to: [ Ссылка ]

2- To watch the second (The Neuromuscular Junction as the model of the chemical synapse) make sure to go to: [ Ссылка ]

To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.

TIMESTAMPS

0:00 Introduction
0:17 Hippocampus anatomy
2:11 LTP mechanism at the Schaffer Collateral (& late-LTP)
8:17 Plasticity terminology (Input specificity, Cooperativity, Associativity)
12:38 LTP mechanism at the Mossy fiber pathway
13:58 LTD mechanism at the Schaffer Collateral
15:15 Spike-timing-dependent plasticity (STDP)
18:44 Conclusion & citations

RESOURCES

Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)

- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Lodish: Molecular Cell Biology (9th edition)
- Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
- Bünemann, M et al: Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
- Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
- Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
- Stent, G S: A physiological mechanism fo Hebb’s postulate of learning

To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.

CREDITS

Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower ([ Ссылка ])

свернуть