Speaker: Ching-Lung Hsu, Academia Sinica (grid.28665.3f)
Title: Cellular mechanisms for rapidly dynamic neural code in spatial navigation
Emcee: Alberto Antonietti
Backend host: Aditya Iyer
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Presented during Neuromatch Conference 3.0, Oct 26-30, 2020.
Summary: Navigation usually involves complex tasks that require neural representation of environments, with the flexibility to respond to rapidly dynamic behavioral or cognitive variables. For instance, in the hippocampus, a brain area important for navigation, relatively small changes in cues can quickly modulate the neural representation of space. Besides, animals also learn to form such neural maps incorporated with task-relevant information. Remarkably, these processes can happen as promptly as in no more than a few seconds.
Dynamic hippocampal coding likely supports a hallmark complexity of spatial cognition, but the cellular mechanisms are poorly understood. In this talk, I will discuss our recent findings that the rapid and flexible formation and adaptation of place-dependent neural firing could be mediated by nonlinear subcellular integration or via synaptic plasticity, through experiments applying whole-cell patch-clamp recording to CA1 pyramidal neurons in acute hippocampal slices and in awake, behaving mice, as well as computational modeling. These results suggest a cellular and biophysical basis for neural computations fundamental to flexible and adaptive behavior.
