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Video Summary:
Na+K+2Cl- cotransporter located at ascending limb of loop of Henle plays important role in not only Na+ but also water absorption. Its effect is multiplied by countercurrent multiplier. This in turn increases medullary osmolarity. Now this hyperosmolarity drives water absorption from distal tubule.
Mechanism of action of loop diuretics is inhibition of Na+K+2Cl- cotransporter. So all the effects are reduced. Final result is abolished medullary hyperosmolarity and reduced water reabsorption from DT. The unabsorbed water is lost in urine.

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DISCLAIMER: This video is for education purpose only. Although every effort is made to ensure accuracy of material, viewer should refer to the appropriate regulatory body/authorised websites, guidelines and other suitable sources of information as deemed relevant and applicable. In view of possibility of human error or changes in medical science, any person or organization involved in preparation of this work accepts no responsibility for any errors or omissions or results obtained from use of information in this video.

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