Lipedema, known as lipoedema in Europe, is a chronic disorder of the adipose tissue generally affecting the legs, which causes the legs, and sometimes the arms, but not the feet, to accumulate fatty tissue. Lipedema predominantly effects women only, though there are a few rare cases of it in men. Believed to be hormonal in nature, Lipedema usually is triggered at puberty, but can trigger or worsen during or after pregnancy, at peri-menopause, and following gynecological surgery or any surgery with anesthesia.

Estimates of the incidence of lipedema vary widely, and range as high as 11% of the post-puberty female population. That would mean close to 17 million women in the United States alone. Lipedema has been unrecognized and generally misdiagnosed in the US.

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