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In this video I describe homeostasis, which refers to maintenance of an optimal state, and allostasis, which clarifies that an optimal state is actually a range of possible states depending on context. Next I discuss Hans Selye's theory of General Adaptation Syndrome, which he derived from his work studying the effects of chronic stressors on rats. He found that many different chronic stressors all resulted in swollen adrenal glands, a smaller thymus, and peptic ulcers. He proposed a 3 stage process for coping with stressors: Alarm, Resistance, and Exhaustion. While not all of his conclusions have been validated today, Selye's work began investigation into the negative effects of chronic stress.

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