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The potent synthetic androgen Trestolone, also known as 7α-methyl-19-nortestosterone (MENT), does not require 5α-reduction to exert its' maximal androgenic effects.
It is an AAS which has been under development for potential use as a form of hormonal birth control for men and in androgen replacement therapy for low testosterone levels in men but has never been approved for clinical usage.
Its' development for potential clinical use continued in 1993 up until 2013, after a long stint of inactivity following its' initial studies which began in 1963.
Alternative androgens are being developed for hormonal therapy which may demonstrate greater potency, duration of action, and oral efficacy than Testosterone. MENT is one of those, as it is a potent orally active synthetic 19-norandrogen.
MENT has the potential advantage that it could be used at relatively low doses, is orally bioavailable, and could potentially circumvent some of the negative effects that stem from traditionally used AAS converting to 5α-reduced androgens in modern medicine (such as Testosterone Replacement Therapy resulting in higher levels of systemic DHT) that may raise the risk of benign prostate hyperplasia, accelerate the development of prostate carcinoma, increase the probability of acne breakouts, and exacerbate/substantially expedite androgenic alopecia (male pattern baldness).
Therefore, it was desirable to investigate whether MENT is 5α-reduced in vivo, which could then potentially result in adverse effects similar to those of DHT.
The results from that data are extrapolated in this video and are used as a reference to guide my own personal research into this synthetic AAS.
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#MalePatternBaldness #AndrogenicAlopecia #HormoneReplacementTherapy
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