In this video, Marion Subklewe, MD, LMU Hospital Munich, Munich, Germany, highlights some findings presented at this year’s ASH meeting, where researchers investigated how T-cells and acute myeloid leukemia (AML) cells communicate, and how bispecific antibodies contribute to the formation of a strong immunological synapse. Dr Subklewe explains how conventional bispecifics using only CD3 engagement are less efficient at eliciting a response, and that adding a positive co-stimulatory molecule can result in stronger activation of T-cells. This interview took place at the 63rd ASH Annual Meeting and Exposition congress in Atlanta, GA, 2021.
