A spectrum of neurological manifestations of COVID-19 have been described, affecting both the central and the peripheral nervous system, including movement disorders. Hadi Manji, MA, MB Bchir, MD, FRCP, National Hospital for Neurology, UCLH Foundation Trust, London, UK, shares the latest understanding of the possible mechanisms behind movement disorder presentation in COVID-19 cases. Firstly, strokes, caused by blood vessel inflammation and hypercoagulation of the blood, could lead to movement disorder presentation when occurring in certain regions of the brain. Dr Manji also discusses inflammation and autoimmune-mediated encephalitis as potential causes. It is not yet clear whether there is direct neurovirulence caused by SARS-CoV-2, but studies to date do not suggest viral damage that could cause movement disorders. Dr Manji emphasizes the importance of long-term monitoring for neurodegenerative and other post-infectious complications, such as encephalitis lethargica. This interview took place during the 2021 International Congress of Parkinson's Disease and Movement Disorders.

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