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Molise, the second smallest region in Italy, spans a total area of 4,438 square kilometers. Often overlooked, it is the least known region in the country, perhaps due to its relatively recent establishment in 1963 when the former region of 'Abruzzi e Molise' was divided into two separate entities. Molise shares its borders with Abruzzo to the north, Lazio to the west, Campania and Apulia to the south and east, and the Adriatic Sea to the northeast. The region is divided into two provinces: Campobasso and Isernia.

Termoli, Molise's only major port and its largest seaside resort, offers ferry connections to the famous Tremiti Islands. Although these islands belong to the Puglia region, they are very close and easily accessible from Molise.

Molise stands out as one of Italy's most unspoiled and lesser-known regions. It features medieval hamlets and villages, well-preserved castles and abbeys, archaeological sites, ancient ruins, and pristine natural landscapes. The region is home to two of UNESCO's Italian biosphere reserves, highlighting its ecological significance. Despite its natural riches, Molise remains off the typical tourist path, maintaining its traditional and authentic character. The local economy is primarily based on agriculture, sheep farming, and craftsmanship.

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