#lungcancer #cancerresearch #bodytemperature #circadianpathway #translationalmedicine #sleep

Recent findings highlight that chronic circadian disruption significantly increased lung cancer
growth in animal models. By identifying the genes implicated, the researchers are illuminating
the mysterious link between our sleeping patterns and disease, which could help inform
everything from developing more targeted cancer treatments to better monitoring high-risk
groups.
To figure this out the scientists used a mouse model with expressed KRAS – the most
commonly mutated gene in lung cancer. Half of the mice were housed in a “normal” light
cycle, meaning 12 hours of light and 12 hours of darkness. The other half were housed in
a light cycle meant to resemble that of shift workers’, where the light hours were moved
earlier by eight hours every two or three days.

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