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Dopamine Agonists - Parkinson's Disease ( Part 6 ) - CNS Pharmacology

Parkinson's disease (PD) is a neurodegenerative disease involving a progressive depletion of dopaminergic neurons in the basal ganglia, particularly the substantia nigra. PD usually manifests at approximately 60 years of age. Although PD is considered an idiopathic disease, genetic factors seem to play a role in about 10–15% of cases, and, accordingly, familial clustering has been observed. The typical clinical picture seen in PD is called parkinsonism and features the classical cardinal symptom of bradykinesia along with resting tremor and/or rigidity. Postural instability is another frequent finding. While PD is the main cause, parkinsonism may also result from other factors, e.g., medication (secondary parkinsonism). Atypical parkinsonism may appear similar to PD, but often features additional or atypical symptoms. To date, there is no cure for PD. Symptomatic treatment includes physical therapy and, depending on patient age and individual symptoms, various medications (e.g., levodopa, dopamine agonists). In specific cases, deep brain stimulation (DBS) surgery may be beneficial.

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