If you are moderately addicted to coffee and you have a passing interest in autophagy and the destruction of senescent/zombie cells then these new studies are definitely worth looking into.

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This is a review of a piece that I read in Lifeapps.io written by Zach Lawton, in it he covers a study published in the journal ‘Biochemical and Biophysical Research Communication’ that investigated how caffeine induces autophagy. All the studies included in this review regarding coffee relate only to the consumption of black coffee without additives and/or sweeteners. Coffee is one of the most widely consumed beverages in the world, there are literally thousands of different types of brews, roasts and blends, and everyone including me has their favourite. Good then that this humble bean can have such a profound effect on our longevity, that is provided that you are also practicing some kind of fasting protocol. A comprehensive review published in the Annual Review of Nutrition focused on coffee and caffeine consumption and its various health outcomes. A meta-analysis of observational and randomized controlled trials suggests that there are many potential health benefits, and obviously some risks, but overall there is a reduced risk of mortality associated with coffee consumption. A study published in the journal of Biochemical and Biophysical Research Communication investigated the power of caffeine to induce autophagy in the skeletal muscle of rats. The researchers concluded that caffeine promoted AMPK-dependent autophagy through calcium-mediated pathways in the skeletal muscle. This does not mean that high levels of caffeine are necessarily required for maximizing the effects of autophagy in your cells, but a little caffeine early in your day may boost that valuable autophagy induced cellular recycling period as you fast. Autophagy is a process of cellular recycling; Autophagy is the Greek for self-eating, so at the cellular level your body becomes cannibalistic and eats the senescent or zombie cells that are weak and no use to us anymore. Fasting-induced autophagy has also been shown to dramatically increase the amount autophagy that takes place in our liver, heart, muscle and even brain tissue. When you fast for around 12 hours or more, you enter a metabolic state called ketosis. In this state, your body starts to break down and burn fat instead of glucose. Some of this fat is used by the liver to produce ketones, they serve as an alternative energy source for your brain cells and cells in other tissues when glucose isn’t readily available. When the body is depleted of glucose or sugar, the insulin signaling pathway and mTOR pathways that are responsible for cellular growth are inhibited or in other words “temporarily turned off.” This inhibition of the “Mammalian Target of Rapamycin” or mTOR pathway signals to the body that the genes responsible for cellular growth can take a break, while the genes responsible for fat metabolism, stress resistance and damage repair should be turned on through the (AMPK) pathway. In a second study that was published in the journal ‘Cell Cycle’, researchers looked at the effects of both caffeinated and non-caffeinated coffee on autophagy. They found that both natural and decaffeinated brands of coffee resulted in rapid autophagy in mice 1-4 hours after coffee consumption. This increase in autophagy was observed in the liver, the heart and in muscle tissues.
DISCLAIMER: This video and description contain discount codes, which means that if you use the code, I will receive a small commission. FAIR-USE COPYRIGHT DISCLAIMER
Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, commenting, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational, or personal use tips the balance in favor of fair use. #caffeine #coffee #autophagy

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