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With leaky gut syndrome sold as the root cause of many diseases, a whole new marketplace has opened up for supplement manufacturers.

But are they effective? That's the topic of this video.

Leaky Gut Supplements and Probiotics:
Do They Work?

In a previous video we explained what Leaky Gut is, and how it is more or less a marketable way to describe impaired intestinal permeability.

For all the new leaky gut supplements available, there's actually been no clinical trials on supplements for intestinal permeability, except glutamine.

Glutamine is currently the most popular leaky gut supplement. It’s an amino acid used as a fuel source by cells in the gut. However, the weight of evidence has failed to show benefits as a supplement in humans.

Almost all studies use intravenous glutamine (injected) on hospitalised patients with Crohn’s disease. So it’s real world application as an oral supplement is purely speculative.

STUDY - [ Ссылка ]
A 2012 human trial supplementing oral glutamine each day found it only normalised intestinal permeability in 8 of 14 participants (57%), after 2 months (28).

However, 8 of 14 participants in the control group – who were supplementing an equal amount of whey protein powder instead – also normalised intestinal permeability, indicating glutamine supplementation has no beneficial effects over whey protein powder, if it’s even beneficial at all.

"Intestinal permeability normalized in 8 (57.1%) patients in each group. Intestinal permeability and morphology improved significantly in both glutamine and active control group (whey protein powder)."

Probiotics - which are bacteria that we eat for health benefits - have also been proposed as a beneficial supplement for leaky gut.

STUDY- [ Ссылка ], [ Ссылка ]

It’s suspected that bacteria in the gut can influence intestinal permeability, and early mice studies suggest probiotic supplementation can positively affect intestinal permeability.
Unfortunately it’s not yet understood what strains are beneficial for humans, and at what dosages.

So that's where the science is at regarding supplements for intestinal gut health.

Any leaky gut supplements that claim to be "Scientifically-proven" or "clinically- proven" are not. Those research terms have been kind of bastardised by supplement manufacturers to establish credibility.

My best advice before you buy is to ask questions and think critically about how extreme the health claims are. If it sounds too good to be true, unfortunately it is.

Thanks for watching if you enjoyed this and found it useful please give a thumbs up and leave a comment. And if you're watching on youtube be sure to subscribe to the Diet vs Disease channel by clicking the red button below so that you don't miss other videos like this one.

Dietitian: Joe Leech (MSc Nutrition)

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