Massimo Filippi, MD, Vita-Salute San Raffaele University, Milan, Italy, discusses the impact of incorporating functional connectivity analyses in multiple sclerosis (MS). The human functional connectome helps determine the MS phenotype of patients, but most importantly, it helps understand how lesions in different brain regions affect clinical manifestations. Functional connectivity analyses have provided insights into the well-known discrepancy between clinical and MRI findings on why small lesions in critical brain regions or hubs can lead to significant clinical phenomenology. This interview took place at the 2022 Congress of the European Academy of Neurology (EAN) in Vienna, Austria.
