Here is how to the best, useful and legit potions possible. You will need to max out your equipment through the enchanting loop including vampirism.

The Most Expensive Potion:

Giants Toe + Wheat + Scaly Pholiata

The best enchanting potion:

(Any 2) Snowberries, Hagraven Claw, Spriggan Sap, Blue Butterfly Wing

The best smithing potion:

(Any 2) Blisterwort, Glowing Mushroom, Sabre Cat Tooth, Spriggan Sap

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