In this cutting edge discussion, Drs. Karima Hirani and Deanna Minich discuss pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), honing in on its clinical presentation, assessment, and treatment options in both pediatric and adult patients.

PANDAS is thought to arise from the development of brain-reactive autoantibodies following infection by a group A streptococcus (GAS). PANDAS is an episodic condition typified by a sudden onset of obsessive compulsive disorder (OCD) and involuntary movement disorder (e.g., tics), usually following a strep infection. Other patients may not have a classical history of a strep infection, but have been asymptomatic carriers of the strep infection nonetheless.

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