Air date: Wednesday, June 24, 2009, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: About Dr. Hsiao Ashe's Lecture:

"We have performed studies involving the creation of transgenic mouse models of Alzheimer's disease in order to understand how the amyloid-ß and tau proteins impair memory and cognition. The work has shown that the aggregates of amyloid-ß and tau proteins which define Alzheimer's disease neuropathologically do not cause cognitive deficits in mice. These investigations have led to the discovery of a form of the amyloid-ß protein called Aß star (Aß*) that disrupts cognitive function in mice and rats, and increases in humans before a diagnosis of Alzheimer's disease has been made. We propose that Alzheimer's disease begins when Aß* levels rise, triggering a cascade of events that culminates in neurodegeneration and dementia."

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.

Author: Karen Hsiao Ashe, MD, PhD, University of Minnesota
Runtime: 01:03:34
Permanent link: [ Ссылка ]

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