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The brain’s memory-retrieval network is composed of many interacting regions. In a new study, Caltech researchers looked at the interaction between two nodes in this network: the medial frontal cortex (frontal lobe) and the hippocampal-amygdala complex (temporal lobe). Human volunteers were asked to transition between a task that does not require memory retrieval (a categorization task) and one that does require retrieval. The researchers observed that neural activity in the frontal lobe is organized by theta-wave oscillations in the temporal lobe only during memory retrieval, much like a conductor would lead a musical ensemble. Successful retrieval of a memory depends on this interaction.
